Two Tier Hox Collinearity Mediates Vertebrate Axial Patterning
نویسندگان
چکیده
منابع مشابه
Hox patterning of the vertebrate axial skeleton.
The axial skeleton in all vertebrates is composed of similar components that extend from anterior to posterior along the body axis: the occipital skull bones and cervical, thoracic, lumbar, sacral, and caudal vertebrae. Despite significant changes in the number and size of these elements during evolution, the basic character of these anatomical elements, as well as the order in which they appea...
متن کاملHox patterning of the vertebrate rib cage.
Unlike the rest of the axial skeleton, which develops solely from somitic mesoderm, patterning of the rib cage is complicated by its derivation from two distinct tissues. The thoracic skeleton is derived from both somitic mesoderm, which forms the vertebral bodies and ribs, and from lateral plate mesoderm, which forms the sternum. By generating mouse mutants in Hox5, Hox6 and Hox9 paralogous gr...
متن کاملHox genes and the evolution of vertebrate axial morphology.
A common form of evolutionary variation between vertebrate taxa is the different numbers of segments that contribute to various regions of the anterior-posterior axis; cervical vertebrae, thoracic vertebrae, etc. The term 'transposition' is used to describe this phenomenon. Genetic experiments with homeotic genes in mice have demonstrated that Hox genes are in part responsible for the specifica...
متن کاملHox collinearity - a new perspective.
Hox collinearity is a spectacular phenomenon that has excited life scientists since its discovery in 1978. Two mechanisms have been proposed to explain the spatially sequential pattern of Hox gene expression in animal embryonic development: interactions among Hox genes, or the progressive opening of chromatin in the Hox clusters, from 3' to 5'. A review of the evidence across different species ...
متن کاملThe Role of Hox Genes in Axial Patterning in Hydra1
SYNOPSIS. Hox genes in bilaterians specify distinct regions along the anteriorposterior axis. A question of interest is when in metazoan evolution did this class of genes take on this function. Hox genes have been isolated from a number of cnidarian species including hydra. The expression patterns of two of them, Cnox3 and Cnox-2 have been examined in adult hydra. Cnox-3, a labial homologue, pl...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2018
ISSN: 2296-634X
DOI: 10.3389/fcell.2018.00102